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The nanoform can radically alter polyphenol effects

05 September 2012

A study, published online today [04 September 2012] in Nanomedicine, compared the properties of polyphenols in different forms on white blood cells taken from patients with colorectal cancer and from healthy volunteers. It found that the known antioxidant properties of these substances can be reversed when they are used in their nanoparticle form. Antioxidants prevent damage to DNA and other molecules which can be caused by free radicals.

Led by Professor Diana Anderson from Bradford’s School of Life Sciences, the research compared the antioxidant responses of two polyphenols, called ECGC and theaflavins. These were provided by Dr Gupta, Director of the Indian Institute of Toxicology Research (IITR).The findings showed that when used in bulk form, these polyphenols exhibited their anticipated antioxidant responses, but the nanoform at higher concentrations had the reverse effect and exhibited statistically significant pro-oxidant effects, which can cause increased DNA damage…..

Read more: http://www.nanotech-now.com/news.cgi?story_id=45901


Written by csirindia

September 10, 2012 at 10:14 am

Posted in IITR

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