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CSIR-run institutes make good headway in tracing new molecules against diabetes, asthma, CAD

19 June 2012

NEW DELHI: The efforts to develop new molecules to treat diabetes, schizophrenia, asthma, pancreatitis, and coronary artery disease, have made good progress during the last five years under different institutes of Council of Science and Industrial Research (CSIR), according to an assessment report.

“Indian Institute of Chemical Biology (IICB) synthesized nearly 400 new molecules based on the selected anti-diabetic drug targets i.e. DPP-IV, PTP1b and GLP-1, alpha-glucosidase, glucose-6-phosphatase, glycogen phosphorylase, and aldose reductase and evaluated against their putative targets. Three new molecules showed inhibition against PTP1b, whereas nine new molecules showed inhibition against DPP-IV. One of glucose-6-phosphatase and two alpha-glucosidase inhibitors showed anti-hyperglycaemic activity on streptozotocin-induced diabetic rats,” according to the report……

Read more: http://pharmabiz.com/NewsDetails.aspx?aid=69640&sid=1

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Written by csirindia

June 22, 2012 at 5:29 am

Posted in CSIR

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