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Move afoot to develop low-cost drug for TB

27 March 2011

NEW DELHI:

With the world struggling to find out an effective drug against tuberculosis for the past five decades, a group of young Indian researchers has come forward to take up the challenge.
The team is scrutinising two promising molecules created by pharmaceutical companies to develop  a new low-cost drug  for India, its neighbours and Africa as drug companies have agreed on providing non-exclusive licensing rights for the developing world, sources told Deccan Herald.

Rifampicin was the last TB medicine discovered in 1963. Since then scientists all over the world are trying to find out new drugs and vaccines against TB without much success so far. The risks involved in drug development are too high.

That is the reason TB Alliance—a global agency funded by pharmaceutical companies and non-profit outfits like Bill Gates Foundation —has turned to India’s Open Source Drug Discovery (OSDD) platform looking for a break.

Two months ago, TB Alliance brought two molecules to OSDD. The first one is PA 824 developed by US scientists from the industry and universities in 2000 while the second molecule was developed by AstraZeneca in Bangalore three years ago. None have come anywhere close to the market, though the laboratory studies were promising.

The OSDD team at the Council of Scientific and Industrial Research will study the two molecules threadbare in-silicon to find out the potential risks and benefits in the long run. The team will decide whether these molecules could be taken up for phase-II clinical trial costing millions….

Read more: http://www.deccanherald.com/content/149362/move-afoot-develop-low-cost.html

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Written by csirindia

March 28, 2011 at 9:30 am

Posted in CSIR

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