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CSIR to Provide Affordable Healthcare with Global Partnership

23 March 2011

March 24 is the World TB Day. India has the world’s largest TB epidemic in terms of incidence and mortality and the disease remains the largest killer of Indians between the ages of 15 and 45. In order to find new drugs for TB, CSIR had initiated the Open Source Drug Discovery (OSDD) project which was launched on 15th September, 2008.

In the past two years OSDD has gathered momentum as an internationally recognised open innovation model. Today, OSDD has more than 4500 registered users from over 130 countries. The offshoot of OSDD is a new model of imparting higher education to young aspirant scientists in remote areas of India and of nations less endowed with scientific opportunities.

New initiatives taken by CSIR

1. Setting up of an OSDD Chemistry laboratory at CSIR-IICT Hyderabad, exclusively dedicated to synthesis of potential anti TB compounds.

2. Large scale screening of molecules against TB to find novel molecules which may end up as new TB drugs. For this, CSIR laboratories will open up its small molecule libraries, from synthetic as well as natural sources

3. Sequencing Mtb strains in large numbers to study variation in Mycobacterium tuberculosis (Mtb). This is an Open Screening Facility where all researchers who are having interesting TB strains are welcome to contribute them to OSDD. These strains will be synthesised and results will be available on OSDD open portal.

4. A collaboration with ICMR to bring clinicians and researchers together for improving TB drug research.

5. OSDD will extend to other neglected diseases like Malaria.

Open Source Drug Discovery Initiative for Malaria

The early success of the Mtb OSDD programme has presented a model for the way drug discovery research for infectious diseases may move in the future. As the next step, CSIR proposes to initiate a pan-India open source program for malaria with global participation.

In extension of the OSDD paradigm, the malaria initiative proposes to expand on wet lab approaches while retaining and building upon the computational approaches that have yielded important results in the area of tuberculosis.

Researchers in malaria as well as interested students and individuals from other fields are invited to participate….

Read more: http://pib.nic.in/newsite/erelease.aspx?relid=71218

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Written by csirindia

March 26, 2011 at 12:20 am

Posted in CSIR

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